MovDisordV3, France, Analysis, bibRecord, 000524

Linkage exclusion in French families with probable Parkinson's disease

Identifieur interne : 000524 ( France/Analysis ); précédent : 000523; suivant : 000525

Linkage exclusion in French families with probable Parkinson's disease

Auteurs : Matt Farrer [États-Unis] ; Alain Destée [France] ; Estelle Becquet [France] ; Fabienne Wavrant-De Vrièze [États-Unis, France] ; Vincent Mouroux [France] ; Florence Richard [France] ; Luc Defebvre [France] ; Sarah Lincoln [États-Unis] ; John Hardy [États-Unis] ; Philippe Amouyel [France] ; Marie-Christine Chartier-Harlin [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2000-11.

RBID : ISTEX:4908AE8C762CF83107D8176D132C01FA7B0D193D

Descripteurs français

Pascal (Inist)
- Caractère autosomique, Caractère dominant, Déterminisme génétique, Etude familiale, Français, Haplotype, Homme, Liaison génétique, Mutation, Parkinson maladie, Protéine tau, Ubiquitin carboxy-terminal hydrolase, α-Synucléine.
Wicri :
- geographic : France.
- topic : Génétique, Homme.

English descriptors

KwdEn :
- Adult, Age of Onset, Aged, Autosomal character, Chromosomes, Human, Pair 17 (genetics), Chromosomes, Human, Pair 2 (genetics), Chromosomes, Human, Pair 4 (genetics), Chromosomes, Human, Pair 6 (genetics), Cluster Analysis, Dominant character, Family study, Female, France, French, Genetic Linkage, Genetic determinism, Genetics, Haplotype, Haplotypes, Human, Humans, Ligases (genetics), Linkage, Male, Middle Aged, Mutation, Nerve Tissue Proteins (genetics), Parkinson Disease (diagnosis), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Pedigree, Sex Distribution, Synucleins, Tau protein, Thiolester Hydrolases (genetics), Ubiquitin Thiolesterase, Ubiquitin hydrolase, Ubiquitin-Protein Ligases, alpha-Synuclein, tau, tau Proteins (genetics), α‐synuclein.
MESH :
- chemical , genetics : Ligases, Nerve Tissue Proteins, Thiolester Hydrolases, tau Proteins.
- geographic : France, Synucleins, Ubiquitin Thiolesterase, Ubiquitin-Protein Ligases, alpha-Synuclein.
- diagnosis : Parkinson Disease.
- genetics : Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 2, Chromosomes, Human, Pair 4, Chromosomes, Human, Pair 6, Parkinson Disease.
- Adult, Age of Onset, Aged, Cluster Analysis, Female, Genetic Linkage, Haplotypes, Humans, Male, Middle Aged, Mutation, Pedigree, Sex Distribution.

Abstract

We analyzed the segregation of genetic markers spanning chromosomal regions 2p13, 4p14‐15, 4q21‐23, 6q25‐27, and 17q21 in nine French families affected by autosomal‐dominant probable Parkinson's disease. These regions have been linked or associated with familial Parkinson's disease. Multipoint linkage and haplotype analyses excluded 2p13 and 4p14‐15 loci in five of nine families. For three families, which were equivocal for two‐point linkage at D4S405, the ubiquitin carboxy‐terminal hydrolase gene (UCH‐L1) was sequenced. In one family, a novel UCH‐L1 M124L mutation that did not segregate with early‐onset disease was identified. This suggests that rare variants in this gene may not be pathogenic. In seven of nine families, it could be inferred that affected individuals did not share 4q21‐23 (α‐synuclein) haplotypes. All families were unequivocally excluded by haplotype analysis from the parkin locus on 6q25‐27. Finally, the 17q21 region was excluded in four of nine families, and no mutation in the tau gene was identified in the five remaining families. Findings from this study confirm genetic heterogeneity within familial parkinsonism.

Url:

https://api.istex.fr/document/4908AE8C762CF83107D8176D132C01FA7B0D193D/fulltext/pdf

DOI: 10.1002/1531-8257(200011)15:6<1075::AID-MDS1004>3.0.CO;2-2

Affiliations:

Links to Exploration step

ISTEX:4908AE8C762CF83107D8176D132C01FA7B0D193D

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Linkage exclusion in French families with probable Parkinson's disease</title>
<author><name sortKey="Farrer, Matt" sort="Farrer, Matt" uniqKey="Farrer M" first="Matt" last="Farrer">Matt Farrer</name>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Becquet, Estelle" sort="Becquet, Estelle" uniqKey="Becquet E" first="Estelle" last="Becquet">Estelle Becquet</name>
</author>
<author><name sortKey="Wavrant E Vrieze, Fabienne" sort="Wavrant E Vrieze, Fabienne" uniqKey="Wavrant E Vrieze F" first="Fabienne" last="Wavrant-De Vrièze">Fabienne Wavrant-De Vrièze</name>
</author>
<author><name sortKey="Mouroux, Vincent" sort="Mouroux, Vincent" uniqKey="Mouroux V" first="Vincent" last="Mouroux">Vincent Mouroux</name>
</author>
<author><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Lincoln, Sarah" sort="Lincoln, Sarah" uniqKey="Lincoln S" first="Sarah" last="Lincoln">Sarah Lincoln</name>
</author>
<author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
</author>
<author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:4908AE8C762CF83107D8176D132C01FA7B0D193D</idno>
<date when="2000" year="2000">2000</date>
<idno type="doi">10.1002/1531-8257(200011)15:6<1075::AID-MDS1004>3.0.CO;2-2</idno>
<idno type="url">https://api.istex.fr/document/4908AE8C762CF83107D8176D132C01FA7B0D193D/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001916</idno>
<idno type="wicri:Area/Istex/Curation">001916</idno>
<idno type="wicri:Area/Istex/Checkpoint">003235</idno>
<idno type="wicri:doubleKey">0885-3185:2000:Farrer M:linkage:exclusion:in</idno>
<idno type="wicri:Area/Main/Merge">007332</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:01-0017636</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002A86</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000235</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002B74</idno>
<idno type="wicri:doubleKey">0885-3185:2000:Farrer M:linkage:exclusion:in</idno>
<idno type="wicri:Area/Main/Merge">007566</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:11104189</idno>
<idno type="wicri:Area/PubMed/Corpus">003E76</idno>
<idno type="wicri:Area/PubMed/Curation">003E76</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003F47</idno>
<idno type="wicri:Area/Ncbi/Merge">000375</idno>
<idno type="wicri:Area/Ncbi/Curation">000375</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000375</idno>
<idno type="wicri:doubleKey">0885-3185:2000:Farrer M:linkage:exclusion:in</idno>
<idno type="wicri:Area/Main/Merge">007090</idno>
<idno type="wicri:Area/Main/Curation">004A35</idno>
<idno type="wicri:Area/Main/Exploration">004A35</idno>
<idno type="wicri:Area/France/Extraction">000524</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Linkage exclusion in French families with probable Parkinson's disease</title>
<author><name sortKey="Farrer, Matt" sort="Farrer, Matt" uniqKey="Farrer M" first="Matt" last="Farrer">Matt Farrer</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Clinique Neurologique, Central and Regional Hospital, Lille Cedex</wicri:regionArea>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Becquet, Estelle" sort="Becquet, Estelle" uniqKey="Becquet E" first="Estelle" last="Becquet">Estelle Becquet</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Clinique Neurologique, Central and Regional Hospital, Lille Cedex</wicri:regionArea>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wavrant E Vrieze, Fabienne" sort="Wavrant E Vrieze, Fabienne" uniqKey="Wavrant E Vrieze F" first="Fabienne" last="Wavrant-De Vrièze">Fabienne Wavrant-De Vrièze</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Clinique Neurologique, Central and Regional Hospital, Lille Cedex</wicri:regionArea>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM 508, Institut Pasteur de Lille, Lille Cedex</wicri:regionArea>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mouroux, Vincent" sort="Mouroux, Vincent" uniqKey="Mouroux V" first="Vincent" last="Mouroux">Vincent Mouroux</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM 508, Institut Pasteur de Lille, Lille Cedex</wicri:regionArea>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM 508, Institut Pasteur de Lille, Lille Cedex</wicri:regionArea>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Clinique Neurologique, Central and Regional Hospital, Lille Cedex</wicri:regionArea>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Lincoln, Sarah" sort="Lincoln, Sarah" uniqKey="Lincoln S" first="Sarah" last="Lincoln">Sarah Lincoln</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM 508, Institut Pasteur de Lille, Lille Cedex</wicri:regionArea>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM 508, Institut Pasteur de Lille, Lille Cedex</wicri:regionArea>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
<wicri:noRegion>Lille Cedex</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2000-11">2000-11</date>
<biblScope unit="vol">15</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="1075">1075</biblScope>
<biblScope unit="page" to="1083">1083</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">4908AE8C762CF83107D8176D132C01FA7B0D193D</idno>
<idno type="DOI">10.1002/1531-8257(200011)15:6<1075::AID-MDS1004>3.0.CO;2-2</idno>
<idno type="ArticleID">MDS1004</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Autosomal character</term>
<term>Chromosomes, Human, Pair 17 (genetics)</term>
<term>Chromosomes, Human, Pair 2 (genetics)</term>
<term>Chromosomes, Human, Pair 4 (genetics)</term>
<term>Chromosomes, Human, Pair 6 (genetics)</term>
<term>Cluster Analysis</term>
<term>Dominant character</term>
<term>Family study</term>
<term>Female</term>
<term>France</term>
<term>French</term>
<term>Genetic Linkage</term>
<term>Genetic determinism</term>
<term>Genetics</term>
<term>Haplotype</term>
<term>Haplotypes</term>
<term>Human</term>
<term>Humans</term>
<term>Ligases (genetics)</term>
<term>Linkage</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Pedigree</term>
<term>Sex Distribution</term>
<term>Synucleins</term>
<term>Tau protein</term>
<term>Thiolester Hydrolases (genetics)</term>
<term>Ubiquitin Thiolesterase</term>
<term>Ubiquitin hydrolase</term>
<term>Ubiquitin-Protein Ligases</term>
<term>alpha-Synuclein</term>
<term>tau</term>
<term>tau Proteins (genetics)</term>
<term>α‐synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ligases</term>
<term>Nerve Tissue Proteins</term>
<term>Thiolester Hydrolases</term>
<term>tau Proteins</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term>
<term>Synucleins</term>
<term>Ubiquitin Thiolesterase</term>
<term>Ubiquitin-Protein Ligases</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 17</term>
<term>Chromosomes, Human, Pair 2</term>
<term>Chromosomes, Human, Pair 4</term>
<term>Chromosomes, Human, Pair 6</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Cluster Analysis</term>
<term>Female</term>
<term>Genetic Linkage</term>
<term>Haplotypes</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Pedigree</term>
<term>Sex Distribution</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Caractère autosomique</term>
<term>Caractère dominant</term>
<term>Déterminisme génétique</term>
<term>Etude familiale</term>
<term>Français</term>
<term>Haplotype</term>
<term>Homme</term>
<term>Liaison génétique</term>
<term>Mutation</term>
<term>Parkinson maladie</term>
<term>Protéine tau</term>
<term>Ubiquitin carboxy-terminal hydrolase</term>
<term>α-Synucléine</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
<term>Homme</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We analyzed the segregation of genetic markers spanning chromosomal regions 2p13, 4p14‐15, 4q21‐23, 6q25‐27, and 17q21 in nine French families affected by autosomal‐dominant probable Parkinson's disease. These regions have been linked or associated with familial Parkinson's disease. Multipoint linkage and haplotype analyses excluded 2p13 and 4p14‐15 loci in five of nine families. For three families, which were equivocal for two‐point linkage at D4S405, the ubiquitin carboxy‐terminal hydrolase gene (UCH‐L1) was sequenced. In one family, a novel UCH‐L1 M124L mutation that did not segregate with early‐onset disease was identified. This suggests that rare variants in this gene may not be pathogenic. In seven of nine families, it could be inferred that affected individuals did not share 4q21‐23 (α‐synuclein) haplotypes. All families were unequivocally excluded by haplotype analysis from the parkin locus on 6q25‐27. Finally, the 17q21 region was excluded in four of nine families, and no mutation in the tau gene was identified in the five remaining families. Findings from this study confirm genetic heterogeneity within familial parkinsonism.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>États-Unis</li>
</country>
<region><li>Floride</li>
<li>Nord-Pas-de-Calais</li>
</region>
<settlement><li>Lille</li>
</settlement>
<orgName><li>Université Lille 2</li>
<li>Université Lille Nord de France</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Floride"><name sortKey="Farrer, Matt" sort="Farrer, Matt" uniqKey="Farrer M" first="Matt" last="Farrer">Matt Farrer</name>
</region>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<name sortKey="Lincoln, Sarah" sort="Lincoln, Sarah" uniqKey="Lincoln S" first="Sarah" last="Lincoln">Sarah Lincoln</name>
<name sortKey="Wavrant E Vrieze, Fabienne" sort="Wavrant E Vrieze, Fabienne" uniqKey="Wavrant E Vrieze F" first="Fabienne" last="Wavrant-De Vrièze">Fabienne Wavrant-De Vrièze</name>
</country>
<country name="France"><region name="Nord-Pas-de-Calais"><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
</region>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<name sortKey="Becquet, Estelle" sort="Becquet, Estelle" uniqKey="Becquet E" first="Estelle" last="Becquet">Estelle Becquet</name>
<name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
<name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<name sortKey="Mouroux, Vincent" sort="Mouroux, Vincent" uniqKey="Mouroux V" first="Vincent" last="Mouroux">Vincent Mouroux</name>
<name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name>
<name sortKey="Wavrant E Vrieze, Fabienne" sort="Wavrant E Vrieze, Fabienne" uniqKey="Wavrant E Vrieze F" first="Fabienne" last="Wavrant-De Vrièze">Fabienne Wavrant-De Vrièze</name>
<name sortKey="Wavrant E Vrieze, Fabienne" sort="Wavrant E Vrieze, Fabienne" uniqKey="Wavrant E Vrieze F" first="Fabienne" last="Wavrant-De Vrièze">Fabienne Wavrant-De Vrièze</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000524 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000524 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     ISTEX:4908AE8C762CF83107D8176D132C01FA7B0D193D
   |texte=   Linkage exclusion in French families with probable Parkinson's disease
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Linkage exclusion in French families with probable Parkinson's disease

Linkage exclusion in French families with probable Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.